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Function
Protein binding:Selectively binds to other protein complexes non-covalently. 1a4y also works to inhibit ANG in order to inhibit angiogenesis, along with RNASE1 to inhibit an endonuclease that cleaves phosphodiester bonds, and RNASE2 .
Disease
has a role in cancers and tumor growth. A mutation in 1a4y which results in increased activity of Ang could lead to tumor growth. Ang has also been theorized as a protector of the central nervous system and thus under-production of 1a4y may result in limited Ang and thus neurodegenerative diseases.
Relevance
Structural highlights
Ribonuclease Inhibitor-The unusual non-globular structure of ribonuclease inhibitor, its solvent parallel Beta-sheet and the conformational flexibility of the structure are used in the interaction. These structures make the ribonuclease inhibitor an effective binding protein.
Angiogenin-
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
