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1a8f
From Proteopedia
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HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE
Overview
The N-lobe of human serum transferrin (hTF/2N) has been expressed in baby, hamster kidney cells and crystallized in both orthorhombic (P212121) and, tetragonal (P41212) space groups. Both crystal forms diffract to high, resolution (1.6 and 1.8 A, respectively) and have been solved by molecular, replacement. Subsequent refinement resulted in final models for the, structure of hTF/2N that had crystallographic R-factors of 18.1 and 19.7%, for the two crystal forms, respectively; these models represent the, highest-resolution transferrin structures determined to date. The hTF/2N, polypeptide has a folding pattern similar to those of other transferrins, including the presence of a deep cleft that contains the metal-binding, site. In contrast to other transferrins, both crystal forms of hTF/2N, ... [(full description)]
About this Structure
1A8F is a [Single protein] structure of sequence from [Homo sapiens] with CO3 and FE as [ligands]. Full crystallographic information is available from [OCA].
Reference
Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release., MacGillivray RT, Moore SA, Chen J, Anderson BF, Baker H, Luo Y, Bewley M, Smith CA, Murphy ME, Wang Y, Mason AB, Woodworth RC, Brayer GD, Baker EN, Biochemistry. 1998 Jun 2;37(22):7919-28. PMID:9609685
Page seeded by OCA on Mon Oct 29 17:30:42 2007
Categories: Homo sapiens | Single protein | Anderson, B.F. | Baker, E.N. | Baker, H. | Bewley, M. | Brayer, G.D. | Chen, J. | Luo, Y. | Macgillivray, R.T.A. | Mason, A.B. | Moore, S.A. | Murphy, M.E.P. | Smith, C.A. | Wang, Y. | Woodworth, R.C. | CO3 | FE | Carbonate | Glycoprotein | Iron transport | Iron-release | Nlobe | Transferrin
