Structural highlights
Function
[GIN_BACSU] An anti-sigma-G factor, prevents premature activation of sigma-G factor in the forespore; overexpression leads to 1000-fold reduction in spore formation, spore formation stops after engulfment (PubMed:17921305, PubMed:19497328). Overexpression also inhibits sigma-G transcription activation activity (PubMed:18208527). When both Gin and sigma-G are expressed in E.coli Gin inhibits sigma-G, strongly suggesting Gin inhibits by direct physical interaction (PubMed:19497328).[1] [2] [3]
References
- ↑ Chary VK, Xenopoulos P, Piggot PJ. Expression of the sigmaF-directed csfB locus prevents premature appearance of sigmaG activity during sporulation of Bacillus subtilis. J Bacteriol. 2007 Dec;189(23):8754-7. doi: 10.1128/JB.01265-07. Epub 2007 Oct 5. PMID:17921305 doi:http://dx.doi.org/10.1128/JB.01265-07
- ↑ Karmazyn-Campelli C, Rhayat L, Carballido-Lopez R, Duperrier S, Frandsen N, Stragier P. How the early sporulation sigma factor sigmaF delays the switch to late development in Bacillus subtilis. Mol Microbiol. 2008 Mar;67(5):1169-80. doi: 10.1111/j.1365-2958.2008.06121.x., Epub 2008 Jan 15. PMID:18208527 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06121.x
- ↑ Rhayat L, Duperrier S, Carballido-Lopez R, Pellegrini O, Stragier P. Genetic dissection of an inhibitor of the sporulation sigma factor sigma(G). J Mol Biol. 2009 Jul 31;390(5):835-44. doi: 10.1016/j.jmb.2009.05.073. Epub 2009 , Jun 1. PMID:19497328 doi:http://dx.doi.org/10.1016/j.jmb.2009.05.073
