Sandbox Reserved 1391

From Proteopedia

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Contents 1 Overview 2 Function 3 Relevance 4 Structural highlights 5 References

Overview

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This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.

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DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.

Function

As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes. The two most important subunits of this polymerase are the α subunit that links the nucleotides together via a phosphodiester bond and the ε subunit that ensures the bases are accurate via proofreading mechanisms. It can synthesize base pairs at a rate of about 1000 nucleotides per second and can only move in the 5' to 3' direction.

Relevance

Structural highlights

This enzyme contains many different regions that all have different properties. These are the of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions. </StructureSection>

References