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Pho4
From Proteopedia
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sturcture
The structure of the Pho4 protein is a basic Helix-loop-helix(bHLH) , The linker sequence between Helix1(H1) and Helix2(H2) contains several residues: Asn, Glu, Pro and Ser[6]. The DNA binding site is a homodimer and two monomers in a left‐handed four‐helix bundle fold (identical to bHLH/Zip and bHLH proteins fold) [7].
loop structure Pho4 loops (conserved structure?) are long but compact and forms a short alpha-helical structure [5]. The PHO4 loop contains a Trp residue that faces the aromatic rings of Tyr52 and His55 of helix H2, and Pro28 of H2 and H1.an aromatic cluster forms a cap structure is observed.
3D Structures of lactoferrin
Updated on 19-March-2018
1a0a – yPho4 DNA-binding domain + DNA - yeast
3w3x – yPho4 peptide + importin subunit b-3
References
- ↑ Berben G, Legrain M, Gilliquet V, Hilger F. The yeast regulatory gene PHO4 encodes a helix-loop-helix motif. Yeast. 1990 Sep-Oct;6(5):451-4. PMID:2220078 doi:http://dx.doi.org/10.1002/yea.320060510
Proteopedia Page Contributors and Editors (what is this?)
Inbar Yaffe, Michal Harel, Alexander Berchansky, Joel L. Sussman
