User:Emily Lawson/Sandbox 1
From Proteopedia
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Poly(A) Binding Protein (PABP)- Homo sapiens
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Human Poly(A) Binding Protein (PABP) is a biopolypeptide involved in recognizing the 3'poly (A) tail of mRNA that is added to an mRNA transcript during mRNA processing.This recognition as well as PABP's interaction with other proteins and initiation factors causes it to also play a significant role in translation initiation and mRNA stabilization and degradation. PABP consists of four conserved domains of RNA recognition motifs (RRMs); however, the two N-terminal RRMs (RRM1 and RRM2) and the short linker sequence that connects them supports most of the function of PABP, so RRM3 and RRM4 may not be essential. Thus, the published X-ray structure exhibits RRM1 and RRM2 at a 2.6 Angstrom resolution.
Function
Poly (A)Binding
Translation Initiation
Disease
Relevance
Structural highlights
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