User:Evie Nguyen/Sandbox 1
From Proteopedia
Contents |
HRP1
HRP1 is found in Saccharomyces cerevisiae, commonly known as "baker's yeast." It was discovered via solution NMR and then released to the RCSB Protein Data Bank with the ID "2CJK" in 2006. HRP1 is the RNA recognition domain of the Cleavage Factor Complex, positioning the RNA cleavage site prior to polyadenylation. It is composed of 2 RNA binding domains that recognize a specific 5'-AUAUAU-3' sequence of RNA.
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This is a default text for your page Evie Nguyen/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
RNA Binding
The ribonucleotides of the recognized sequence 5'-AUAUAU-3' are designated from 5'-3' Ade2, Ade4, and Ade6; and Ura3, Ura5, and Ura7. The first two bases, Ade2 and Ura3, bind to the second RNA binding domain, and the remaining bases of the sequence bind to the first RNA binding domain. Each ribonucleotide has distinguishing interactions with the protein including
Adenines
Disease
Relevance
Structural highlights
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
