4-hydroxy-3-methylbut-2-enyl diphosphate reductase

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spinqualitylabelsall models Structure of E. coli Fe4S4-containing IspH complex with substrate HMBPP ( PDB code 3szl). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function 4-hydroxy-2-methylbut-2-enyl diphosphate reductase (IspH or HMBPP reductase) is an containing protein. IspH converts 1-hydroxy-2-methylbut-2-enyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). IspH participates in isoprenoid biosynthesis. IspH is the last enzyme in the nonmevalonate pathway. [1] Disease IspH is involved in penicillin tolerance. Structural highlights is shown. . Of note, . . (PDB code 3szl).[2]

3D structures of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Updated on 11-April-2018

References

1. ↑ Rekittke I, Wiesner J, Rohrich R, Demmer U, Warkentin E, Xu W, Troschke K, Hintz M, No JH, Duin EC, Oldfield E, Jomaa H, Ermler U. Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. J Am Chem Soc. 2008 Dec 24;130(51):17206-7. PMID:19035630 doi:http://dx.doi.org/10.1021/ja806668q
2. ↑ Span I, Grawert T, Bacher A, Eisenreich W, Groll M. Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis. J Mol Biol. 2011 Nov 23. PMID:22137895 doi:10.1016/j.jmb.2011.11.033