2gvf
From Proteopedia
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| , resolution 2.50Å | |||||||
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| Ligands: | , | ||||||
| Related: | 1A1R, 2FM2, 1RGQ, 2A4G, 2A4R, 2A4Q
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021
Overview
Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.
About this Structure
2GVF is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease., Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V, Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. Epub 2006 May 30. PMID:16730985
Page seeded by OCA on Mon Mar 31 03:22:10 2008
