Cystic fibrosis transmembrane conductance regulator (CFTR)

The CFTR is a chloride channel, and is regulated by PKA phosphorylation, cAMP levels, and ATP/ADP ratios. Mutations in the CFTR cause the disease cystic fibrosis.

One feature of the CFTR is a Walker motif, which is found in ATP binding proteins.It is also known as a P (or phosphate binding) loop.

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Function

Disease

Relevance

Structural highlights