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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
It is unclear if there is a normal function of human trypsin IV, but there is research suggesting that it has a role in neural development (1). However, it is mostly associated with neurodegenerative diseases such as Alzheimer’s (2). It is found in glial cells and astrocytes (2). It breaks down proteins in the brain and forms protein aggregates called amyloids (2). These sticky structures eventually harden and form plaque.
One of this protein’s original residues changes to form the version of the protein that causes Alzheimer’s, dementia, and other mental disorders (1,2). Its 193rd residue is Glycine, but when it becomes Arginine, it disrupts normal activity (2). There are inhibitors in the brain that block this protein, but the version with Arg193 causes steric hindrance in the active site of its inhibitor (2). Another feature of this protein that is problematic is its positive charge, which also interferes with the inhibitor (2).
Disease
Relevance
Structural highlights
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