Dehalogenase

Function

Dehalogenases catalyze the removal of halogen atom from substrates.
• Haloalkane dehalogenase converts haloalkanes to alcohol^[1]
• Halohydrin dehalogenase converts halohydrins to epoxide
• L-2 haloacid dehalogenase converts L-2-haloacids to D-2-hydroxyacid
• S-2 haloacid dehalogenase converts S-2-haloacids to R-2-hydroxyacid
• 4-chlorobenzoyl CoA dehalogenase converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA
• Fluoroacetate dehalogenase converts fluoroacetate to glycolate
• Iodotyrosine dehalogenase converts iodotyrosine to tyrosine
• cis- and trans-3-chloroacrylic acid dehalogenase converts 3-chloroacrylate to malonate semialdehyde
• 5-chloromuconolactone dehalogenase converts 5-chloromuconolactone to E-dienelactone.
• Tetrachloroethene reductive dehalogenase catalyzes the conversion of trichloroethene, Cl- and acceptor to tetrachloroethene and reduced acceptor.

Relevance

Haloalkane dehalogenase is tested for the biodegredation of toxic industrial by-products. Fluoroacetate dehalogenase is tested for the biodegredation of the poisonous fluroacetate which can kill livestock and is found in some plants in Australia, Africa and Central America.

Structural highlights

In the fluoroacetate dehalogenase complex with halide, the (in cyan).^[2]