Structural highlights
Publication Abstract from PubMed
- Loganin is an iridoid glycoside of interest as both an intermediate in the biosynthesis of indole alkaloids in plants and as a bioactive compound itself. The loganic acid methyltransferase catalyzes the methylation of a monoterpenoid glycoside precursor to produce loganin, and demonstrates stereospecificity for the (6S,7R) substrate. Here, we biochemically characterize this biocatalyst and elucidate the basis for its strict substrate specificity. These studies may help facilitate the design of new classes of monoterpenoid indole alkaloids of pharmaceutical interest.
Loganic Acid Methyltransferase: Insights into the specificity of methylation on an iridoid glycoside.,Petronikolou N, Hollatz A, Schuler MA, Nair SK Chembiochem. 2018 Feb 5. doi: 10.1002/cbic.201700679. PMID:29399933[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Petronikolou N, Hollatz A, Schuler MA, Nair SK. Loganic Acid Methyltransferase: Insights into the specificity of methylation on an iridoid glycoside. Chembiochem. 2018 Feb 5. doi: 10.1002/cbic.201700679. PMID:29399933 doi:http://dx.doi.org/10.1002/cbic.201700679
