Background
The development of high-throughput genome squencing allowed proteins to be sequenced more quickly than their structures could be solved. In an effort to close this gap, in 2000, the National Institutes of Health launched the 15-year Protein Structure Initiative. Solved structures are deposited in the Protein Data Bank, but many proteins, such as YxiM (PDB ID: 2O14), remain functionally uncharacterized. YxiM originates from Bacillus subtilis, a ubiquitous bacterial species that dwells in soil and gastrointestinal tracts. YxiM is 375 amino acids in length and its molecular weight is 41.8 kDa. It appears to have two domains: one dominated by α-helices, and one by β-sheets.
Methods
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Future Directions
