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2i39
From Proteopedia
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| , resolution 2.20Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | N1L (VACWR028) (Vaccinia virus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Vaccinia virus N1L protein
Overview
Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.
About this Structure
2I39 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.
Reference
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957
Page seeded by OCA on Mon Mar 31 03:39:05 2008
