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2i39

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Revision as of 00:39, 31 March 2008 by OCA (Talk | contribs)
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Image:2i39.gif


PDB ID 2i39

Drag the structure with the mouse to rotate
, resolution 2.20Å
Ligands:
Gene: N1L (VACWR028) (Vaccinia virus)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Vaccinia virus N1L protein


Overview

Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.

About this Structure

2I39 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957

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