2i6e
From Proteopedia
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| , resolution 2.50Å | |||||||
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| Ligands: | , | ||||||
| Gene: | DR_0370 (Deinococcus radiodurans) | ||||||
| Domains: | COG1427 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178
Overview
BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.
About this Structure
2I6E is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.
Reference
X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:17908300
Page seeded by OCA on Mon Mar 31 03:40:22 2008
Categories: Deinococcus radiodurans | Single protein | Burley, S K. | Kumaran, D. | NYSGXRC, New York Structural GenomiX Research Consortium. | Swaminathan, S. | Tyagi, R. | Hypothetical protein,pfam:duf178 | New york structural genomix research consortium | Nysgxrc,10093b | Protein structure initiative | Psi-2 | Structural genomic | Unknown function
