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2icw

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Revision as of 00:42, 31 March 2008 by OCA (Talk | contribs)
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Image:2icw.gif


PDB ID 2icw

Drag the structure with the mouse to rotate
, resolution 2.410Å
Ligands:
Gene: HLA-DRA (Homo sapiens), HLA-DRB1 (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule


Overview

'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.

About this Structure

2ICW is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Mycoplasma arthritidis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC., Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H, Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14. PMID:17220897

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