Beta-ketoacyl-ACP reductase

Function

Beta-ketoacyl carrier protein reductase (BKACPR) catalyzes the reaction of conversion of 3-hydroxyacyl-[acyl-carrier-protein] to 3-oxoacyl-[acyl-carrier-protein] while using NADPH as a reducing agent. BKACPR is part of the type II fatty acid biosynthesis pathway. Pimelyl carrier protein reductase (ACPR) is involved in the assembly pathway of the pimeloyl moiety of biotin.

Relevance

BKACPR from Plasmodium falciparium inhibitors are tested as antimalarial drugs. Other BKACPR inhibitors are tested for combating toxoplasmosis and sleeping sickness.

Structural highlights

The interacting with co-factor NADPH contains the active site catalytic triad (in E. coli, PDB code 1q7b).^[1] Water molecules are shown as red spheres.