User:Luis Netto/Sandbox 1

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Contents 1 Ohr 2 Disease 3 Relevance 4 Structural highlights 5 References

Ohr

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Ohr (Organic Hydroperoxide Resistance Protein)1zb8 is a Cys based peroxidase [1],[2] that display higher preference for hydrogen peroxide (H2O2) than for organic hydroperoxides. Accordingly, bacteria with the gene for Ohr deleted displayed increased sensitivity for organic hydroperoxides but not for hydrogen peroxide [3]. Ohr is a tight homo-dimer a Function Ohr is a Cys based peroxidase that means the active site Cys is very reactive towards organic hydroperoxides. This high reactivity is achieved in the active site by interactions with fully conserved Arg and Glu residues among others Your Heading Here (maybe something like 'Structure') Anything in this section will appear adjacent to the 3D structure and will be scrollable.

It is involved in the response of

Disease

Relevance

Structural highlights

Arg19 and Glu 50 of one chain (lets say chain A) compose the triad with Cys61 of the other chain (in this case chain B).

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References

1. ↑ Cussiol JR, Alves SV, de Oliveira MA, Netto LE. Organic hydroperoxide resistance gene encodes a thiol-dependent peroxidase. J Biol Chem. 2003 Mar 28;278(13):11570-8. doi: 10.1074/jbc.M300252200. Epub 2003 , Jan 22. PMID:12540833 doi:http://dx.doi.org/10.1074/jbc.M300252200
2. ↑ Lesniak J, Barton WA, Nikolov DB. Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr. EMBO J. 2002 Dec 16;21(24):6649-59. PMID:12485986
3. ↑ Mongkolsuk S, Praituan W, Loprasert S, Fuangthong M, Chamnongpol S. Identification and characterization of a new organic hydroperoxide resistance (ohr) gene with a novel pattern of oxidative stress regulation from Xanthomonas campestris pv. phaseoli. J Bacteriol. 1998 May;180(10):2636-43. PMID:9573147