Structural highlights
Disease
[LARP7_HUMAN] Microcephalic primordial dwarfism, Alazami type. The disease is caused by mutations affecting the gene represented in this entry.
Function
[LARP7_HUMAN] Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.[1] [2]
References
- ↑ He N, Jahchan NS, Hong E, Li Q, Bayfield MA, Maraia RJ, Luo K, Zhou Q. A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. Mol Cell. 2008 Mar 14;29(5):588-99. Epub 2008 Jan 31. PMID:18249148 doi:http://dx.doi.org/S1097-2765(08)00036-1
- ↑ Markert A, Grimm M, Martinez J, Wiesner J, Meyerhans A, Meyuhas O, Sickmann A, Fischer U. The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. EMBO Rep. 2008 Jun;9(6):569-75. Epub 2008 May 16. PMID:18483487 doi:http://dx.doi.org/embor200872
