Structural highlights
Function
[IF4E_YEAST] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. [EAP1_YEAST] Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.[1] [2] [3]
References
- ↑ Cosentino GP, Schmelzle T, Haghighat A, Helliwell SB, Hall MN, Sonenberg N. Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Mol Cell Biol. 2000 Jul;20(13):4604-13. PMID:10848587
- ↑ Chial HJ, Stemm-Wolf AJ, McBratney S, Winey M. Yeast Eap1p, an eIF4E-associated protein, has a separate function involving genetic stability. Curr Biol. 2000 Nov 30;10(23):1519-22. PMID:11114520
- ↑ Matsuo R, Kubota H, Obata T, Kito K, Ota K, Kitazono T, Ibayashi S, Sasaki T, Iida M, Ito T. The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation. FEBS Lett. 2005 Apr 25;579(11):2433-8. doi: 10.1016/j.febslet.2005.03.043. PMID:15848184 doi:http://dx.doi.org/10.1016/j.febslet.2005.03.043
