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2nq3

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Revision as of 01:06, 31 March 2008 by OCA (Talk | contribs)
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Image:2nq3.gif


PDB ID 2nq3

Drag the structure with the mouse to rotate
, resolution 1.80Å
Ligands:
Gene: ITCH (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase


Overview

We have cloned a new protein that interacts with the hematopoietic DNA-binding transcription factor, p45/NF-E2, by screening a human erythroleukemia cell cDNA library with the yeast two-hybrid approach. Predicted peptide sequence and chromosomal mapping identified the cloned molecule to be the product of the human ortholog of the mouse Itch gene, which has been implicated previously in the regulation of growth and differentiation of erythroid and lymphoid cells. Transfection experiments indicate that this human ITCH protein can act as a transcriptional corepressor of p45/NF-E2. Our data provide novel insights into the functional roles of the mammalian ITCH proteins in the development of hematopoietic cell lineages.

About this Structure

2NQ3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2., Chen X, Wen S, Fukuda MN, Gavva NR, Hsu D, Akama TO, Yang-Feng T, Shen CK, Genomics. 2001 Apr 15;73(2):238-41. PMID:11318614

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