2jrf

Structural highlights

Function

[TPPP3_HUMAN] Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Biochemistry. 2006 Nov 21;45(46):13818-26. PMID:17105200 doi:http://dx.doi.org/10.1021/bi061305e
2. ↑ Zhou W, Wang X, Li L, Feng X, Yang Z, Zhang W, Hu R. Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation. Mol Cell Biochem. 2010 Jan;333(1-2):91-8. doi: 10.1007/s11010-009-0208-0. Epub, 2009 Jul 25. PMID:19633818 doi:http://dx.doi.org/10.1007/s11010-009-0208-0