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Mechanism
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Structure and Sequence
The gene encoding CYP3A4 is located on chromosome 7 in the human genome[6] and it has been found that there are significant variants of the protein correlating to race [7]. This finding is relevant due to the proteins altered ability to react with substrates such as testosterone [8].
The Show:Asymmetric Unit Biological Assembly, QSbio confidence: Low
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can be seen colored in rainbow succession from the N to C terminus. The protein pocket, where the reactions are catalyzed, more specifically, the heme binding site contains twenty-two residues [5] but the main interaction is with a Cysteine at position 442, which coordinates with iron.
