Structural highlights
Disease
[ANO10_HUMAN] Adult-onset autosomal recessive cerebellar ataxia. The disease is caused by mutations affecting the gene represented in this entry.
Function
[ANO10_HUMAN] Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.[1] [2]
References
- ↑ Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, Kunzelmann K. Expression and function of epithelial anoctamins. J Biol Chem. 2010 Mar 5;285(10):7838-45. doi: 10.1074/jbc.M109.065367. Epub 2010 , Jan 7. PMID:20056604 doi:http://dx.doi.org/10.1074/jbc.M109.065367
- ↑ Tian Y, Schreiber R, Kunzelmann K. Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci. 2012 Nov 1;125(Pt 21):4991-8. doi: 10.1242/jcs.109553. Epub 2012 Sep , 3. PMID:22946059 doi:http://dx.doi.org/10.1242/jcs.109553
