2ot8
From Proteopedia
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| , resolution 3.1Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | TNPO1, KPNB2, MIP1, TRN (Homo sapiens), HNRPM (Homo sapiens) | ||||||
| Related: | 1qbk, 2h4m
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Karyopherin Beta2/Transportin-hnRNPM NLS Complex
Overview
Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.
About this Structure
2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768
Page seeded by OCA on Mon Mar 31 04:22:43 2008
