5ybz

Structural highlights

Function

[C1QL3_MOUSE] May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production.^{[1] [2]}

References

1. ↑ Bolliger MF, Martinelli DC, Sudhof TC. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2534-9. doi: 10.1073/pnas.1019577108., Epub 2011 Jan 24. PMID:21262840 doi:http://dx.doi.org/10.1073/pnas.1019577108
2. ↑ Wei Z, Peterson JM, Wong GW. Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. J Biol Chem. 2011 May 6;286(18):15652-65. doi: 10.1074/jbc.M110.201087. Epub 2011, Mar 4. PMID:21378161 doi:http://dx.doi.org/10.1074/jbc.M110.201087