Structural highlights
2x05 is a 2 chain structure with sequence from "streptomyces_orientalis"_pittenger_and_brigham_1956 "streptomyces orientalis" pittenger and brigham 1956. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 2vzr, 2vzu, 2vzs, 2vzt, 2vzo, 2vzq, 2vzp, 2vzv |
| Activity: | Exo-1,4-beta-D-glucosaminidase, with EC number 3.2.1.165 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The synthesis of amino-derivatives of castanospermine and australine and their characterisation as inhibitors of the exo-beta-D-glucosaminidase CsxA through enzyme kinetics and X-ray structural analysis is described.
Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue.,Pluvinage B, Ghinet MG, Brzezinski R, Boraston AB, Stubbs KA Org Biomol Chem. 2009 Oct 21;7(20):4169-72. Epub 2009 Aug 14. PMID:19795054[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Pluvinage B, Ghinet MG, Brzezinski R, Boraston AB, Stubbs KA. Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue. Org Biomol Chem. 2009 Oct 21;7(20):4169-72. Epub 2009 Aug 14. PMID:19795054 doi:10.1039/b913235j
