User:Jaime.Prilusky/Test/Sortable

This self-assembling structure has an interior cavity about 32 Å in diameter. It consists of 24 palladium ions, each of which is coordinated by 4 nitrogens, which are part of 48 dipyridylthiophene molecules. Such synthetic nano-spheres can be functionalized to create synthetic receptors and nanoreactors. Potential applications in sensing, catalysis, and drug delivery are being explored.

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by Eric Martz
A historical review on sculptures and physical models of macromolecules.

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G Atilla-Gocumen, L Di Costanzo, E Meggers. J Biol Inorg Chem. 2010 doi: 10.1007/s00775-010-0699-x
A crystal structure of an organometallic half-sandwich ruthenium complex bound to glycogen synthase kinase 3ß (GSK-3ß) reveals that the inhibitor binds to the ATP binding site via an induced fit mechanism utilizing several hydrogen bonds and hydrophobic interactions. Importantly, the metal is not involved in any direct interaction with the protein kinase but fulfills a purely structural role.

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Touching stretches cell membranes, opening mechanosensitive ion channels, leading to sensation by the nervous system. Pictured is the transmembrane region of a similar channel in bacteria. When closed, the narrow opening is lined by hydrophobic amino acid sidechains, making it non-conductive to ions.

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