6e7d

Structural highlights

Function

[CLC2D_MOUSE] Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).^{[1] [2] [3] [4] [5]} [KRBBB_MOUSE] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.^{[6] [7]}

References

1. ↑ Zhou H, Kartsogiannis V, Hu YS, Elliott J, Quinn JM, McKinstry WJ, Gillespie MT, Ng KW. A novel osteoblast-derived C-type lectin that inhibits osteoclast formation. J Biol Chem. 2001 May 4;276(18):14916-23. Epub 2001 Feb 13. PMID:11278931 doi:http://dx.doi.org/10.1074/jbc.M011554200
2. ↑ Zhou H, Kartsogiannis V, Quinn JM, Ly C, Gange C, Elliott J, Ng KW, Gillespie MT. Osteoclast inhibitory lectin, a family of new osteoclast inhibitors. J Biol Chem. 2002 Dec 13;277(50):48808-15. Epub 2002 Oct 8. PMID:12374791 doi:http://dx.doi.org/10.1074/jbc.M209059200
3. ↑ Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3527-32. Epub 2004 Feb 27. PMID:14990792 doi:http://dx.doi.org/10.1073/pnas.0308304101
4. ↑ Gange CT, Quinn JM, Zhou H, Kartsogiannis V, Gillespie MT, Ng KW. Characterization of sugar binding by osteoclast inhibitory lectin. J Biol Chem. 2004 Jul 9;279(28):29043-9. Epub 2004 May 3. PMID:15123656 doi:http://dx.doi.org/10.1074/jbc.M312518200
5. ↑ Carlyle JR, Mesci A, Ljutic B, Belanger S, Tai LH, Rousselle E, Troke AD, Proteau MF, Makrigiannis AP. Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. J Immunol. 2006 Jun 15;176(12):7511-24. PMID:16751398
6. ↑ Iizuka K, Naidenko OV, Plougastel BF, Fremont DH, Yokoyama WM. Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Nat Immunol. 2003 Aug;4(8):801-7. Epub 2003 Jul 13. PMID:12858173 doi:http://dx.doi.org/10.1038/ni954
7. ↑ Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3527-32. Epub 2004 Feb 27. PMID:14990792 doi:http://dx.doi.org/10.1073/pnas.0308304101