| Structural highlights
Function
[RNY_BACSU] Endoribonuclease that initiates mRNA decay. Initiates the decay of all SAM-dependent riboswitches, such as yitJ riboswitch. Involved in processing of the gapA operon mRNA, it cleaves between cggR and gapA (PubMed:19193632). Is also the decay-initiating endonuclease for rpsO mRNA.[1] [2] [3] [4] [5]
References
- ↑ Commichau FM, Rothe FM, Herzberg C, Wagner E, Hellwig D, Lehnik-Habrink M, Hammer E, Volker U, Stulke J. Novel activities of glycolytic enzymes in Bacillus subtilis: interactions with essential proteins involved in mRNA processing. Mol Cell Proteomics. 2009 Jun;8(6):1350-60. doi: 10.1074/mcp.M800546-MCP200. Epub, 2009 Feb 3. PMID:19193632 doi:http://dx.doi.org/10.1074/mcp.M800546-MCP200
- ↑ Shahbabian K, Jamalli A, Zig L, Putzer H. RNase Y, a novel endoribonuclease, initiates riboswitch turnover in Bacillus subtilis. EMBO J. 2009 Nov 18;28(22):3523-33. doi: 10.1038/emboj.2009.283. Epub 2009 Sep, 24. PMID:19779461 doi:http://dx.doi.org/10.1038/emboj.2009.283
- ↑ Yao S, Bechhofer DH. Initiation of decay of Bacillus subtilis rpsO mRNA by endoribonuclease RNase Y. J Bacteriol. 2010 Jul;192(13):3279-86. doi: 10.1128/JB.00230-10. Epub 2010 Apr, 23. PMID:20418391 doi:http://dx.doi.org/10.1128/JB.00230-10
- ↑ Durand S, Gilet L, Bessieres P, Nicolas P, Condon C. Three essential ribonucleases-RNase Y, J1, and III-control the abundance of a majority of Bacillus subtilis mRNAs. PLoS Genet. 2012;8(3):e1002520. doi: 10.1371/journal.pgen.1002520. Epub 2012 Mar , 8. PMID:22412379 doi:http://dx.doi.org/10.1371/journal.pgen.1002520
- ↑ Figaro S, Durand S, Gilet L, Cayet N, Sachse M, Condon C. Bacillus subtilis mutants with knockouts of the genes encoding ribonucleases RNase Y and RNase J1 are viable, with major defects in cell morphology, sporulation, and competence. J Bacteriol. 2013 May;195(10):2340-8. doi: 10.1128/JB.00164-13. Epub 2013 Mar 15. PMID:23504012 doi:http://dx.doi.org/10.1128/JB.00164-13
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