Sialidase

From Proteopedia

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Sialidase is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances [1]. Trans-sialidase is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface[2], [3]. Disease Relevance Trypanosoma cruzi trans-sialidase is a drug target agains Chagas Disease[4]. Structural highlights

3D structures of salidase

Updated on 06-November-2018

References

1. ↑ Monti E, Preti A, Venerando B, Borsani G. Recent development in mammalian sialidase molecular biology. Neurochem Res. 2002 Aug;27(7-8):649-63. PMID:12374200
2. ↑ Paris G, Ratier L, Amaya MF, Nguyen T, Alzari PM, Frasch AC. A sialidase mutant displaying trans-sialidase activity. J Mol Biol. 2005 Jan 28;345(4):923-34. PMID:15588836 doi:10.1016/j.jmb.2004.09.031
3. ↑ Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. FASEB J. 1993 Oct;7(13):1257-64. PMID:8405811
4. ↑ Miller BR 3rd, Roitberg AE. Trypanosoma cruzi trans-sialidase as a drug target against Chagas disease (American trypanosomiasis). Future Med Chem. 2013 Oct;5(15):1889-900. doi: 10.4155/fmc.13.129. PMID:24144418 doi:http://dx.doi.org/10.4155/fmc.13.129