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Function
Colony-stimulating factors (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells. Three distinct CSFs were characterized[3].
- Granulocyte colony-stimulating factor (G-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils.
- Granulocyte-macrophage colony-stimulating factor (GM-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes.
- Macrophage colony-stimulating factor (M-CSF) act on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages.
Disease
Relevance
Depletin o CSFs have therapeutic benefit in many inflammatory and autoimmune conditions[4].
Structural highlights
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