Structural highlights
Function
[PDCL2_HUMAN] May play a role in germ cell maturation (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.
Structure of the thioredoxin-fold domain of human phosducin-like protein 2.,Lou X, Bao R, Zhou CZ, Chen Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt, 2):67-70. Epub 2009 Jan 31. PMID:19193988[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Lou X, Bao R, Zhou CZ, Chen Y. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt, 2):67-70. Epub 2009 Jan 31. PMID:19193988 doi:10.1107/S1744309108037342
