6baq
From Proteopedia
Mus musculus BPIFA1
Structural highlights
Function[BPIA1_MOUSE] Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (By similarity). Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.[1] Publication Abstract from PubMedBacterial permeability-increasing family member A1 (BPIFA1) is an innate immunity factor and one of the most abundantly secreted proteins in the upper airways. BPIFA1 is multifunctional, with antimicrobial, surfactant and lipopolysaccharide-binding activities, as well as established roles in lung hydration. Here, the 2.5 A resolution crystal structure of BPIFA1 from Mus musculus (mBPIFA1) is presented and compared with those of human BPIFA1 (hBPIFA1) and structural homologs. Structural distinctions between mBPIFA1 and hBPIFA1 suggest potential differences in biological function, including the regulation of a key pulmonary ion channel. Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1.,Little MS, Redinbo MR Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):268-276. doi:, 10.1107/S2053230X18004600. Epub 2018 Apr 16. PMID:29717993[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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