Base stacking

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Base stacking is a common arrangement of nucleobases found in the three dimensional structure of nucleic acids. Bases (or base pairs) are planar, and these planes stack at contact distance (about 3.4 Angstrom), excluding water and maximizing Van der Walls interactions. In terms of structural stability, the stacking interactions of bases play a larger role than the hydrogen bonds of the bases for nucleic acids in aqueous solution.[1]

Caption for this structure

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References

  1. ↑ Yakovchuk P, Protozanova E, Frank-Kamenetskii MD. Base-stacking and base-pairing contributions into thermal stability of the DNA double helix. Nucleic Acids Res. 2006 Jan 31;34(2):564-74. doi: 10.1093/nar/gkj454. Print 2006. PMID:16449200 doi:http://dx.doi.org/10.1093/nar/gkj454

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