Structural highlights
Function
[CAH1_HUMAN] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.[1]
Publication Abstract from PubMed
Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.
Selenols: a new class of carbonic anhydrase inhibitors.,Angeli A, Tanini D, Nocentini A, Capperucci A, Ferraroni M, Gratteri P, Supuran CT Chem Commun (Camb). 2018 Dec 18. doi: 10.1039/c8cc08562e. PMID:30560259[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Briganti F, Mangani S, Scozzafava A, Vernaglione G, Supuran CT. Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction? J Biol Inorg Chem. 1999 Oct;4(5):528-36. PMID:10550681
- ↑ Angeli A, Tanini D, Nocentini A, Capperucci A, Ferraroni M, Gratteri P, Supuran CT. Selenols: a new class of carbonic anhydrase inhibitors. Chem Commun (Camb). 2018 Dec 18. doi: 10.1039/c8cc08562e. PMID:30560259 doi:http://dx.doi.org/10.1039/c8cc08562e
