SmpB, also called Small Protein B, is a protein involved in the trans-translation phenomenon. Indeed, SmpB works with tmRNA and translation factors as EF-Tu in order to unblock the ribosome and the mRNA.
SmpB-bound tmRNA functionally mimics a canonical tRNA as a ribonucleoprotein complex (tRNP), during aminoacylation and entry into the ribosome.Moreover, SmpB is the first protein that has been shown to mimic mRNA. SmpB is also the first protein of which stepwise movements in the ribosome are assumed to mimic those of tRNA in the translating ribosome.
Function
enhancement of aminoacylation efficiency of tmRNA, protection of tmRNA from degradation in the cell, and recruitment of tmRNA to the stalled ribosome.
Stabilizing the 3D structure of tmRNA thanks to SmpB loop
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
