Sandbox 1498

From Proteopedia

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Contents 1 3BPU 2 Function 3 Structure 3.1 Primary structure 3.2 Secondary structure 3.3 Tertiary structure 4 References

3BPU

3BPU is a transferase found in Homo sapiens. It is the 3rd PDZ domain of human membrane associated guanylate kinase Q96QZ7, C677S and C709S double mutant. It is encoded by the MAGI1 gene. [1]

Function

3BPU is involved in the cell signalisation. It may play a role as a scaffolding protein at cell-cell junctions. It may also regulate acid-induced ASIC3^[1] currents by modulating its expression at the cell surface through interacting with its PDZ domain.

Structure

Primary structure

3BPU is a one chain structure of 88 amino-acids.

Secondary structure

3BPU structure is composed of 10% of helix (1 left-handed alpha helix; 9 residues) and 40% of beta sheets (8 antiparallel strands; 36 residues).

Tertiary structure

Protéine membranaire donc acides aminés polaires à l'intérieur de la protéine?

Parler des interactions avec les ions Zn https://www.rcsb.org/3d-view/3BPU?preset=ligandInteraction&sele=ZN

References

1. ↑ http://www.rcsb.org/pdb/protein/Q9UHC3