Structural highlights
Function
[MCU_DICDI] Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:24889638). Constitutes a pore-forming and calcium-conducting subunit (PubMed:24889638). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.[UniProtKB:Q8NE86][1]
References
- ↑ Kovacs-Bogdan E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK. Reconstitution of the mitochondrial calcium uniporter in yeast. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8985-90. doi:, 10.1073/pnas.1400514111. Epub 2014 Jun 2. PMID:24889638 doi:http://dx.doi.org/10.1073/pnas.1400514111
