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From Proteopedia
Contents |
Generalities
Clathrin is a 3 legged protein with 3 heavy chains and 3 light chains. It has a triskelion shape and can self-assembled into a polyhedral structure arround vesicles of eukaryotic cells.
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Function
Communication beetween the different compartiments of eukaryotic cell and plasma membrane is allowed by vesicles, wich convey molecules within the cytoplasm. Clathrin are involved in the formation of those vesicles in a process named clathrin mediated endocytosis. Clathrins form a skeleton around the vesicle once several protein are assembled. The coated vesicles like so formed will then lose their round protein skeleton after their departure from the initial compartment because the clathrin cage is dismantled.
Relevance
Structural highlights
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References
Molecular mechanism and physiological functions of clathrin‑mediated endocytosis Harvey T. McMahon and Emmanuel Boucrot
