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Copper is an important metal involed in multiple enzyme catalysed reactions as a cofactor.
Function
Multicopper oxidases are involved in copper homeostasis.Copper as many metal ions is used in multiple biological processes such as detoxification of oxygen free radicals and pigmentation. However copper present in a cell bot bounded to a protein if harmfull and can cause cellular damage. It need to be regulated.
Multicopper oxidase might also be involved in the regulation of metal transport.
Disease
If the amino acids 500 and 501 are mutated from CH to SR, the residual activity and loss of resistance to copper. E. Coli die.
Relevance
Structural highlights
Multicopper Oxidase CueO 4e9s is a protein containing one chain with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 4e9p, 4e9q, 4e9r, 4e9t |
| Gene: | cueO, yacK, b0123, JW0119 (ECOLI) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
