Structural highlights
Disease
[SLMAP_HUMAN] Brugada syndrome.
Function
[SIKE1_HUMAN] Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.[1] [SLMAP_HUMAN] May play a role during myoblast fusion.
References
- ↑ Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J. 2005 Dec 7;24(23):4018-28. doi: 10.1038/sj.emboj.7600863. Epub 2005 Nov, 10. PMID:16281057 doi:http://dx.doi.org/10.1038/sj.emboj.7600863
