5zo2

Structural highlights

Function

[CADM4_MOUSE] Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.^[1] [CADM3_MOUSE] Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.^{[2] [3]}

References

1. ↑ Fukami T, Satoh H, Williams YN, Masuda M, Fukuhara H, Maruyama T, Yageta M, Kuramochi M, Takamoto S, Murakami Y. Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). Gene. 2003 Dec 24;323:11-8. PMID:14659875
2. ↑ Kakunaga S, Ikeda W, Itoh S, Deguchi-Tawarada M, Ohtsuka T, Mizoguchi A, Takai Y. Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J Cell Sci. 2005 Mar 15;118(Pt 6):1267-77. Epub 2005 Mar 1. PMID:15741237 doi:http://dx.doi.org/jcs.01656
3. ↑ Zhou Y, Du G, Hu X, Yu S, Liu Y, Xu Y, Huang X, Liu J, Yin B, Fan M, Peng X, Qiang B, Yuan J. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochim Biophys Acta. 2005 May 20;1669(2):142-54. Epub 2005 Feb 25. PMID:15893517 doi:http://dx.doi.org/S0005-2736(05)00028-3