Function
Tuba or dynamin-binding protein is a scaffold protein found in brain synapses which brings together dynamin and actin regulatory proteins. The N-terminal SH3 domains bind dynamin and the C-terminal SH3 domain binds actin regulatory proteins[1].
For more details see Schubert lab: bacterial InIC disrupts human Tuba complexes.
Disease
Tuba deficiency causes and abnormal renal ciliary and morphogenetic phenotype. Tuba has a critical role in ciliogenesis and nephrogenesis by regulating Cdc42 activity[2].
Structural highlights
Tuba contains 6 SH3 domains. The C-terminal 6th SH3 domain binds proline-rich regions of human actin regulating proteins such as N-WASP and Mena. The peptide forms a polyproline type II helix. The interactions of Tuba with the peptide is via SH3-conserved residues[3].
Tuba 3D structures
See Tuba 3D structures
