CXC chemokine receptor

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spinqualitylabelsall models Human CXCR4/lysozyme chimera complex with antagonist citrulline (PDB code 3oe0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image CXC chemokine receptors bind to cytokines of the CXC chemokine family. CXCR4 is specific for Stromal Derived Factor 1 (SDF-1α, known also as CXCL12). The CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a [1]. CXCR1 recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif.[2] (PDB code 3oe0). . .

3D Structures of CXC chemokine receptor

Updated on 18-February-2019

References

1. ↑ Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 2010 Oct 7. PMID:20929726 doi:10.1126/science.1194396
2. ↑ Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella SJ. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature. 2012 Nov 29;491(7426):779-83. doi: 10.1038/nature11580. Epub 2012 Oct 21. PMID:23086146 doi:http://dx.doi.org/10.1038/nature11580