5zb2

Structural highlights

Function

[RAD7_YEAST] Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. This protein is one of 10 proteins (RAD1, 2,3,4,7,10,14, 16,23 and MMS19) involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.^{[1] [2]} [ELOC_YEAST] Prevents degradation of interacting proteins like PCL6 by the proteasome.^[3]

References

1. ↑ Reed SH, Akiyama M, Stillman B, Friedberg EC. Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair. Genes Dev. 1999 Dec 1;13(23):3052-8. PMID:10601031
2. ↑ Yu S, Owen-Hughes T, Friedberg EC, Waters R, Reed SH. The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair. DNA Repair (Amst). 2004 Mar 4;3(3):277-87. doi: 10.1016/j.dnarep.2003.11.004. PMID:15177043 doi:http://dx.doi.org/10.1016/j.dnarep.2003.11.004
3. ↑ Hyman LE, Kwon E, Ghosh S, McGee J, Chachulska AM, Jackson T, Baricos WH. Binding to Elongin C inhibits degradation of interacting proteins in yeast. J Biol Chem. 2002 May 3;277(18):15586-91. Epub 2002 Feb 25. PMID:11864988 doi:http://dx.doi.org/10.1074/jbc.M200800200