6cf1

Structural highlights

Function

[HIGA_PROVU] Antitoxin component of a type II toxin-antitoxin (TA) system that counteracts the effect of the HigB toxin (PubMed:19423702, PubMed:8645296, PubMed:24257752). Binds to its own promoter and regulates transcription of the higB/higA operon (PubMed:24257752).^{[1] [2] [3]}

References

1. ↑ Hurley JM, Woychik NA. Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites. J Biol Chem. 2009 Jul 10;284(28):18605-13. doi: 10.1074/jbc.M109.008763. Epub, 2009 May 7. PMID:19423702 doi:http://dx.doi.org/10.1074/jbc.M109.008763
2. ↑ Schureck MA, Maehigashi T, Miles SJ, Marquez J, Ei Cho S, Erdman R, Dunham CM. Structure of the P. vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. J Biol Chem. 2013 Nov 20. PMID:24257752 doi:http://dx.doi.org/10.1074/jbc.M113.512095
3. ↑ Tian QB, Ohnishi M, Tabuchi A, Terawaki Y. A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1. Biochem Biophys Res Commun. 1996 Mar 18;220(2):280-4. PMID:8645296 doi:http://dx.doi.org/S0006-291X(96)90396-4