Introduction
The reversible acetylation of lysine residues of histone has been proven to play an important role in the regulation of heterochromatin (inactive) and euchromatin (active). The role of the protein Histone Acetyltransferase is to transfer an acetyl group from Acetyl CoA to a lysine group found on a histone. This results in an increase in gene activity as the addition of acetyl groups to histones results in the formation of euchromatin. In this study we analyzed the structure and function of the HAT1 gene that’s derived from Saccharomyces cerevisiae. We analyzed the various binding sites and interaction mechanisms involved in the acetylation process in addition to the initial Acetyl CoA binding mechanism.
Structure
Domains
Active Site
Hydrophobic Pocket
Mechanism
Protein Gate
Active Residues
Homology to Other Proteins
References
Student Contributors
