6g77

Structural highlights

Function

[KS6A6_HUMAN] Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.^{[1] [2]}

References

1. ↑ Berns K, Hijmans EM, Mullenders J, Brummelkamp TR, Velds A, Heimerikx M, Kerkhoven RM, Madiredjo M, Nijkamp W, Weigelt B, Agami R, Ge W, Cavet G, Linsley PS, Beijersbergen RL, Bernards R. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature. 2004 Mar 25;428(6981):431-7. PMID:15042092 doi:http://dx.doi.org/10.1038/nature02371
2. ↑ Dummler BA, Hauge C, Silber J, Yntema HG, Kruse LS, Kofoed B, Hemmings BA, Alessi DR, Frodin M. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. J Biol Chem. 2005 Apr 8;280(14):13304-14. doi: 10.1074/jbc.M408194200. Epub 2005 , Jan 4. PMID:15632195 doi:http://dx.doi.org/10.1074/jbc.M408194200